An industry-supported center claims that it costs companies $2.6 billion to develop a new drug. But we need a broader-based and more transparent reckoning of research-and-development costs to infor ...

The author describes the scientific foundations of a clinical trial of a first-in-class small-molecule estrogen receptor degrader to treat patients with metastatic breast cancer.

Several barriers to access to preexposure prophylaxis for HIV could be alleviated by making it available over the counter. This step could particularly facilitate access among groups that face stigma.

An 80-year-old woman presented with a 3-day history of abdominal pain. Imaging revealed numerous small gallstones in the gallbladder and cystic duct, consistent with cholecystitis.

Understanding today’s corporatization of U.S. health care requires seeing it from a historical perspective, as a process that began with a change in the business model of care delivery in the 1920s.

The rising tide of chronic kidney disease among patients with type 2 diabetes continues to challenge clinicians and health systems worldwide.1 Advances have been made in the management of chronic k ...

“Corporatization” of health care, a process predicted decades ago, now refers to the general trend throughout the industry toward higher levels of integrated control by consolidated profit-seeking ...

Much of the food consumed in the United States is ultraprocessed. Evidence indicates that ultraprocessed food, as a class, has contributed to high rates of chronic diseases.

A 59-year-old veterinarian presented with a 1-year history of a painful rash on his hand. Verrucous plaques with overlying thick yellow-brown crusting were seen on the dorsum of the hand and the me ...

A 68-year-old man presented with unilateral ptosis. Neurologic examination revealed ptosis of the left eye after a sustained upward gaze. Myasthenia gravis was suspected, and an ice-pack test was p ...

To the Editor: In the 2IQP trial, Kudva and colleagues (May 8 issue) 1 found that in adults with insulin-treated type 2 diabetes, automated insulin delivery (AID) led to a greater reduction in ...

Risks and rewards change during the life cycle of a drug. In the innovation period, drug companies invest in developing new products but cannot sell them. Newly approved drugs initially have exclus ...