Holloway enters as the favorite at -148 (risk $148 to win $100), while Poirier is the underdog at +124 in the latest UFC 318 odds at DraftKings Sportsbook. In the co-main event, Roman Kopylov is the -225 favorite against Paulo Costa (+185) in a middleweight bout.

In the main event, former featherweight champion Max Holloway (26-8 MMA, 22-8 UFC) takes on former interim lightweight champ Dustin Poirier (30-9 MMA, 22-8 UFC). The pair will meet for a third time. Poirier has won both meetings (2012, 2019) and is fighting for the final time in his career in front of his home fans.

Dustin Poirier will receive a hero's welcome in his native Louisiana at UFC 318 when he battles Max Holloway for a third time in their careers. It's a respect Poirier earned from his peers and the promotion that they would take a PPV event to New Orleans for the first time in 25 years as a proper send off to one of the good guys in the sport's history.

Legendary Louisiana-based fighter Dustin Poirier is ready to host fans for his final UFC fight. This weekend, Poirier will face off against Max Holloway

After hinting at the possibility in recent weeks, Poirier (30-9 MMA, 22-8 UFC) confirmed Wednesday that rap legend Lil Wayne will accompany him during his final UFC walk. Lil Wayne's presence won't deter Poirier from sticking with his classic walkout music, however. Poirier will still walk to James Brown's "The Boss" as he long has.