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Gut1d
Extracellular vesicle-induced lipid dysregulation drives liver premetastatic niche formation in colorectal cancer
Background Liver metastasis is a major cause of mortality in patients with colorectal cancer (CRC). Understanding how CRC cells influence the formation of hepatic premetastatic niches (PMNs) is ...
Gut6d
Non-invasive risk-based surveillance of hepatocellular carcinoma in patients with metabolic dysfunction-associated steatotic liver disease
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) affects over 30% of the general population and is ...
Gut3d
Beyond the guideline: lessons in leadership, limits and legacy from the BSG IBD process
The British Society of Gastroenterology’s (BSG) latest 5-year national guideline for inflammatory bowel disease (IBD)1 has recently completed. This adjunct commentary to the guideline contains the ...
gut.bmj24d
Bacteria-metabolite butyrate boosts anti-PD1 efficacy in colorectal cancer patient-derived organoids through activating autologous tumour-infiltrating GNLY+CD8+ T cells | Gut
Figure 2. NaBu combined with anti-PD-1 modulates the cytotoxic subpopulation mainly through the GNLY + CD8 + T cell subset to improve immunotherapy. (A) Uniform manifold approximation and projection ...
gut.bmj7d
Enhancing non-invasive early detection of gastric cancer: a critical reflection on exosome ncRNA and machine learning
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gut.bmj9d
Retraction: Unleashing the potential of exosome ncRNAs for early gastric cancer detection—a critical appraisal of machine learning approaches
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gut.bmj17d
Proton pump inhibitors and the risk of gallbladder cancer: a hospital-based case–control study - Gut
We read with great interest the article by Chuang et al 1 confirming proton pump inhibitor (PPI) use is associated with increased risk of cholecystitis.1 PPIs are a potent class of agents used to ...
gut.bmj19d
Endoscopic variceal ligation versus propranolol for the primary prevention of oesophageal variceal bleeding in patients with hepatocellular carcinoma: an open-label, two-centre ...
Objective This randomised trial aimed to address whether endoscopic variceal ligation (EVL) or propranolol (PPL) is more effective at preventing initial oesophageal variceal bleeding (EVB) in patients ...
gut.bmj19d
Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer | Gut
Background Over a century ago, Virchow proposed that cancer represents a chronically inflamed, poorly healing wound. Normal wound healing is represented by a transitory phase of inflammation, followed ...
gut.bmj19d
Spatial single-cell profiling and neighbourhood analysis reveal the determinants of immune architecture connected to checkpoint inhibitor therapy outcome in hepatocellular ...
Background The determinants of the response to checkpoint immunotherapy in hepatocellular carcinoma (HCC) remain poorly understood. The organisation of the immune response in the tumour ...
gut.bmj21d
The management of adult patients with severe chronic small intestinal dysmotility - Gut
Adult patients with severe chronic small intestinal dysmotility are not uncommon and can be difficult to manage. This guideline gives an outline of how to make the diagnosis. It discusses factors ...