Cluster randomized trials in health care may involve three instead of two levels, for instance, in trials where different interventions to improve quality of care are compared. In such trials, the ...

The selection of suitable outcomes and sample size calculation are critical factors in the design of a randomised controlled trial (RCT). The goal of this study was to identify the range of ...

We conducted this phase 2b, randomized, double-blind, placebo-controlled trial at 61 sites in the United States to evaluate the efficacy and safety of pegozafermin over a treatment period of 24 weeks.

This 56-week, randomized, placebo-controlled trial aimed to evaluate the efficacy and safety of 3.0 mg of liraglutide, injected subcutaneously once daily, as an adjunct to a reduced-calorie diet ...

We present a simple sample-size formula for weighted log-rank statistics applied to clustered survival data with variable cluster sizes and arbitrary treatment assignments within clusters. This ...

Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Recurrence in Breast Noninvasive Neoplasia: A 10-Year Follow-Up of TAM-01 Study The following represents disclosure information ...

A sample size of 160 individuals (80 to each study arm) for this trial was determined on the basis of the F -test to detect a time by treatment group interaction effect at the 5% significance level ...