Anti-PCSK9 antibodies are the jewel in the crown of modern genomic medicine, illustrating what many hope will be a paradigm for future drug discovery.

Barriers such as market access, pricing and reimbursement are affecting the overall growth of the PCSK9 inhibitor class and limiting product use to specific groups of patients. It will take careful ...

PCSK9 inhibitors are given as a shot every 2 or 4 weeks. You’ll need to inject the medicine in your upper arm, stomach, or upper thigh. The doctor will teach you how to do it properly.

For whichever PCSK9 we choose, we get an additional 50% to 60% LDL reduction by using these therapies. So, they work. They lower events. Both trials with PCSK9 inhibitors lowered events by about 15%.

Eli Lilly acquires Verve Therapeutics, Inc. for $1B to advance gene-editing therapies like VERVE-102, targeting ASCVD. Click for more on LLY and VERV.

MedCo. is a one-drug company whose lead asset, inclisiran, is one of several injectable, cholesterol-lowering meds known as PCSK9 inhibitors. And that’s a drug class with a checkered past. The two ...

The first PCSK9 inhibitors that the US Food and Drug Administration approved were monoclonal antibodies, but companies are developing many other modalities. Source: Informa Pharma Intelligence.

PCSK9 inhibitors lower cholesterol and risk for heart disease, but barriers to access exist. A pharmacist-managed cholesterol service can optimize PCSK9 inhibitor access, use and effectiveness.

A large case-control study using genetic proxies for PCSK9 inhibitors may help alleviate concerns that the dyslipidemia agents could promote adverse cardiac remodeling and heart failure.

The PCSK9 inhibitors pose a similar, but in many ways more compelling and complex, set of problems. Their target, hyperlipidemia, is one of the most prevalent conditions in the developed world.

By blocking PCSK9, the monoclonal antibodies make LDL receptors in the liver more available and increase cholesterol-rich LDL clearance from the bloodstream, thereby lowering LDL-cholesterol levels.